Oogenesis: Making the Mos of Meiosis
نویسنده
چکیده
Meiosis is an ancient type of cell division whose advent allowed the evolution of sexual reproduction. The evolutionary history of the specialization that allowed gamete production to emerge from a simple reduction division has been unclear. New data now suggest that the molecular mechanisms involved in animal oocyte specialization may have origins that predate the emergence of bilaterian animals.
منابع مشابه
Mos limits the number of meiotic divisions in urochordate eggs.
Mos kinase is a universal mediator of oocyte meiotic maturation and is produced during oogenesis and destroyed after fertilization. The hallmark of maternal meiosis is that two successive M phases (meiosis I and II) drive two rounds of asymmetric cell division (ACD). However, how the egg limits the number of meioses to just two, thereby preventing gross aneuploidy, is poorly characterized. Here...
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In metazoan oocytes, a metaphase arrest coordinates the completion of meiosis with fertilization. Vertebrate mos maintains the metaphase II arrest of mature oocytes and prevents DNA replication between the meiotic divisions. We identified a Drosophila homolog of mos and showed it to be the mos ortholog by two additional criteria. The dmos transcripts are present in Drosophila oocytes but not em...
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At the end of oogenesis, Xenopus laevis stage VI oocytes are arrested at the G2/M transition (prophase) waiting for progesterone to release the block and begin maturation. Progesterone triggers a cascade of phosphorylation events such as a decrease of pK(a) and an increase of maturating-promoting factor activity. Progression through meiosis was controlled by the sequential synthesis of several ...
متن کاملPhosphorylation of Maskin by Aurora-A participates to the control of sequential protein synthesis during Xenopus laevis oocyte maturation
At the end of oogenesis, Xenopus laevis stage VI oocytes are arrested at the G2/M transition (prophase) waiting for progesterone to release the block and begin maturation. Progesterone triggers a cascade of phosphorylation events such as a decrease of pKA and an increase of MPF activity. Progression through meiosis is controlled by a sequential synthesis of several proteins. For instance, the M...
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During oogenesis, the Xenopus oocyte is blocked in prophase of meiosis I. It becomes competent to resume meiosis in response to progesterone at the end of its growing period (stage VI of oogenesis). Stage IV oocytes contain a store of inactive pre-MPF (Tyr15-phosphorylated Cdc2 bound to cyclin B2); the Cdc25 phosphatase that catalyzes Tyr15 dephosphorylation of Cdc2 is also present. However, th...
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عنوان ژورنال:
- Current Biology
دوره 19 شماره
صفحات -
تاریخ انتشار 2009